Solid-state risk insight within days, not months
Fast CSP is a low-friction entry point into computational polymorph screening and in silico solid-state analysis. Submit your molecular structure and receive an early assessment of competing form risk - with no experimental data or physical sample required to get started. We simply add your experimental form(s) afterwards to the landscape of predicted structures so you get a much clearer picture of your risks and next steps.
A structured low-cost entry point into CMC solid-state analysis
Fast CSP uses the core foundational modules within the BiosimX modular CSP suite to give your development team a structured low-cost entry point into the power of predictive in silico technology for understanding and assessing a target molecule's polymorph landscape.
The Fast CSP workflow is fully computational and can start even before experimental solid-form data or physical material are available.
Rapid turnaround
Receive an early competing form risk assessment within days, not months.
Fixed scope of work
Know upfront what will be analyzed, what will be delivered and when, and at what cost. No software lock-ins, just quality data to help accelerate your program.
No experimental prerequisite
No prior polymorph screening, experimental dataset or physical samples are needed to get started. Let the in silico data put you in charge of your CMC strategy from the outset.
Minimal input. Maximum intelligence.
Fast CSP is designed to remove the barriers that delay solid-form analysis. The input requirements are intentionally minimal.
Molecular structure
As input for our Fast CSP, we only require the basic 2D chemical structure of the target molecule, e.g. SMILES string or InChl, and its basic stereochemistry, e.g. chirality, enantiomers.
Development context
The other essential input for a CSP is a short description of the current stage of development of your molecule and the key solid-state questions that you want to answer so we can tailor the solution to suit.
IP position
Known patents or filing timelines that should inform the solid-form analysis.
A structured risk assessment, ready to act on
Every Fast CSP engagement delivers a consistent set of outputs designed to support clear development decisions and identify practical real-world next steps.
Competing form landscape
A ranked view of plausible competing crystal structures in the energy-density landscape identifying the most stable form(s) within the defined Fast CSP scope of work.
Polymorph risk assessment
Candidate forms are assessed for relative stability, estimated solubility implications and potential development suitability, with key risks prioritized for follow-up.
Initial screening guidance
High-level recommendations for experimental follow-up, helping focus attention on the most relevant risks.
IP form comparison
Where requested, we can compare client-provided patented or otherwise relevant crystal forms against the predicted landscape to support solid-state IP assessment and protection strategy.
Extended screening guidance
A structured review with our team of in silico solid-state experts to discuss the findings, answer questions and agree appropriate next steps.
Expert debrief
If requested, a more detailed set of recommendations for further experimental and in silico screening can be provided, tailored to the predicted landscape and development context.
Early insight across the development program
Fast CSP brings powerful predictive data about competing form risk into development decisions early, putting the power into your hands to steer your program and have critical baseline information to hand when solid-state questions arise later on in development.
Pre-candidate selection
Identify potential polymorph risks before committing significant resources to a development candidate.
IND preparation
Guide solid-form characterization by highlighting plausible competing forms and priorities for experimental follow-up.
Licensing and partnering
Add an independent computational view of polymorph risk to your due diligence package.
IP protection
Relate client-provided IP relevant forms to the predicted crystal landscape.
Formulation planning
Assess competing form stability risks before formulation choices become difficult to change.
Late-stage de-risking
Address unresolved polymorph risks and prioritize the next investigations before making further major investments in development work.
Ready to understand your molecule's competing form risk?
Start with Fast CSP or talk to our team about your development program. No upfront commitment required.
